Also known as African, wild mango and Dika, Irvingia is native to Gabon, a country on the African continent. DEF® successfully processes the hard inner pip (seed) using its unique DCD® technology. Within the seed is contained protein, fibre and fats. Would be good for a Banting Diet

Active: Protein which we offer at 15% purity. (Ratio 4:1)
Usage: Cholesterol management, sugar stability for weight loss amongst others

Blood sugar stability
Weight loss
Leptin sensitivity
Cholesterol management
Satiety promotion

Study

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Introduction

Obesity is of major primary care concern and is targeted as an international health objective in Healthy 2000, which seeks to reduce the prevalence of obesity to less than 20%. In the last 10 years, the number of overweight people has increased from 26 to 34% [1]. Conventional dietary and behavioral treatment have failed in long-term manage- ment. Dietary strategies used to manage obesity include the use of high fibre, low carbohydrates and fats diet [2,3]. Beneficial effect of dietary fibre in the management of obesity is not well established, since their mechanism of action is not known. The discovery of new medicinal plants has led to the creation of potential drugs that mod- ify feeding behavior and metabolism and may therefore have application in weight management. The aim of the present study is to investigate the effect of Irvingia gabon-ensis extract on body weight.

Subjects and methods

A total of 40 obese subjects aged between 19 and 55 years

were selected from a group responding to a radio adver- tisement. After physical examination and laboratory screening tests, diabetics, pregnant and lactating women were excluded. None of these subjects took any weight reducing medication and none was following any specific diet. The purpose, nature and potential risks of the study were explained to all patients and a written informed con- sent was obtained before their participation. The local research ethics committee approved the experimental protocol.

Table 1: Effect of Irvingia gabonensis crude extract on body weight, body fat, waist and hip circumferences

Treatment period (weeks)

0 2 4

Weight (kg Active 105.10 ± 16.98 102.3 ± 17.06 101.01 ± 16.63

Placebo 79.43 ± 9.83 79.43 ± 9.83 79.33 ± 10.63

Active 46.11 ± 4.4848 46.5 ± 3.68 45.34 ± 3.52

Body fat (%) Placebo 40.58 ± 3.49 40.58 ± 3.9 40.3 ± 3.8

Active 112.76 ± 20.5 109.7 ± 20.4 106.6 ± 20.79

Waist (cm) Placebo 81.1 ± 7.1 81,91 ± 7,91 81.25 ± 7.52

Active 125.69 ± 11.34 122.92 ± 10.67 121.15 ± 10.39

Hip (cm) Placebo 122.2 ± 10.7 122.2 ± 10.7 121.5 ± 10.9

Table 2: Effect Irvingia gabonensis on systolic (SBP) and diastolic (DBP) blood pressure

Treatment period (weeks)

0 2 4

SBP (mmHg)	Active	136.41 ± 19.57	132.66 ± 18.48*	132.83 ± 17.97*
	Placebo	134 ± 5.05	121.5 ± 5.89	123.83 ± 2.92
DBP (mmHg)	Active	98.5 ± 19.52	97.5 ± 22.80	94.08 ± 11.07
	placebo	93.50 ± 10.31	93.83 ± 7.41	91.5 ± 6.53

Values are means ± sem. Significant differences were at *P < 0.001 by comparison to the placebo group.

Table 3: The effect of Irvingia gabonensis on blood total cholesterol (TC), triglyceride (TRI), high density lipoprotein cholesterol(HDL-c), low density lipoprotein cholesterol (LDL-c) and glucose.

		T-cholesterol	TRI	HDL-c	LDL-c	LDL/HDL	T-cho/HDL	GLUCOSE
Active	Initial	215 ± 55.12	162 ± 33.15	61.23 ± 20.36	121.37 ± 36.3	1.98 ± 1.78	3.51 ± 2.70	3.8 ± 1.92
	Final	130.68 ± 39.5	89.22 ± 55.63	89.9 ± 28.44	66.08 ± 34.27	0.735 ± 1.20	1.45 ± 1.38	2.57 ± 1.03
Placebo	Initial	163.70 ±25.32	130.65 ±37.82	31.38 ± 25.21	105.06 ±11.86	5.05 ± 3.94	6.44 ± 3.37	3.6 ± 0.41
	Final	158.36 ±30.46	100.52 ±32.55	41.20 ± 19.53	98.55 ± 27.99	3.19 ± 1.85	4.51 ± 2.07	3.9 ± 0.74

Study design

The study was as a randomised, double blind placebo- controlled crossover design, and consisted of a 4-week treatment period. Subjects were given two different types of capsules containing 350 mg of Irvingia gabonensis seed extract (active formulation) or oat bran (placebo). Three capsules were taken three times daily, one-half hour before meals (a total daily amount of 3.15 g of Irvingiagabonensis seed extract) with a glass of warm water. Cap- sules were identical in shape, colour and appearance, with neither patients nor researchers knowing what capsule they received. During the experimental period, subjects
were examined weekly, with their body weight, body fat, waist and hip circumferences recorded each time. Subjec- tive findings such as increased or decreased appetite, feel- ing of lightness and gastrointestinal pains were individually noted. Side effects of the active extract, if any were also solicited and noted during each visit. The sub- jects were also interviewed about their physical activity and food intake during the trial, and were instructed to eat a low fat diet (1800 Kcal) as well as keep a record for seven consecutive days (using household measurements).

Anthropometric measurements

Anthropometric measurements were done at each visit, with body weight and body fat (impedance measurement using a TANITA™ monitor Scale) measurements on fasted (12 hour) subjects wearing light clothing. Waist and hip circumferences were measured by soft non-stretchable plastic tape on the narrowest and the widest parts of the trunk.

Laboratory methods

Blood samples were collected after a 12 h overnight fast into heparinized tubes at the beginning of the study, after two weeks and at the end (4 weeks) of treatment. The con- centrations of total cholesterol, triacylglycerol, HDL-cho- lesterol, and glucose, in plasma were measured using a commercial diagnostic kit (Cholesterol infinity, triglycer- ides Int, EZ HDL™ cholesterol, EZ LDL™ cholesterol, Glu- cose Trinder, respectively) from SIGMA Diagnostics

Statistical Analysis

Results are expressed as mean ± SEM except for anthropo- metric measurements. Paired Student’s t-test was carried out on the start and end values of placebo and Irvingiagabonensis capsules and also on the differences between the placebo and Irvingia gabonensis crude extract.

Results

Effect on body composition

Irvingia gabonensis induced a decrease in weight of 2.91 ± 1.48% (p < 0.0001) after two weeks and 5.6 ± 2.7% (p < 0,0001) after one month. Although the percentage of body fat was not significantly reduced with both placebo and IG, the waist circumference (5.07 ± 3.18%; p < 0.0001) and hip circumference (3.42 ± 2.12%; p < 0,0001) were significantly reduced by IG. A reduction of 1.32 ± 0.41% (p < 0.02) and 2.23 ± 1.05% (p < 0.05) was

observed with the placebo after two and four weeks respectively of treatment.

Effect on blood pressure

From the second week of experimentation, the systolic blood pressure was significantly reduced by the active extract (Table 2).

Effect on blood lipids components

The plasma total cholesterol cencentration was reduced by 39.21%, triglyerides by 44.9% (p < 0,05) and LDL by 45.58%. This was accompanied by a significant increase in HDL-cholesterol of 46.852%. The CT/HDL ratio (p < 0.05) and the blood glucose level were also reduced (32.36%; p < 0.05). No significant change was observed in the placebo group.

Discussion

The soluble fibre of the seed of Irvingia gabonensis like

other forms of water-soluble dietary fibres, are “bulk- forming” laxatives. Irvingia gabonensis seeds delay stomach emptying, leading to a more gradual absorption of dietary sugar. This effect can reduce the elevation of blood sugar levels that is typical after a meal [4]. Controlled studies have found that after-meal blood sugar levels are lower in people with diabetes given glucomannan in their food [5] and overall diabetic control is improved with soluble fibre-enriched diets according to preliminary [6] and con- trolled [7,8] trials. One double-blind study reported that glucomannan (8–13 grams per day) stabilized blood sugar levels in people with the insulin resistance syn- drome [9]. Like other soluble fibers, Irvingia gabonensisseed fibre can bind to bile acids in the gut and carry them out of the body in the faeces, which requires the body to convert more cholesterol into bile acids [10]. This can result in the lowering of blood cholesterol as well as other blood lipids. Controlled double-blind [11,12] studies have shown that supplementation with several grams per day of soluble fibre significantly reduced total blood cho- lesterol, LDL cholesterol, and triglycerides and in some cases raised HDL cholesterol, these being comparable with effects noticed with Irvingia gabonensis.

Considering the wide use of Irvingia gabonensis in the preparation of various dishes in Cameroon, its use should be further encouraged for the purposes of control of die- tary lipids as well as for weight reduction.